The Key to an Effective AIDS Vaccine Now
Not only is there none, but experts project a timeline to discover and prove success of FIFTEEN YEARS!!! This despite the genuine concern of the AIDS vaccine experts who cite the truly horrifying statistics: in some African countries, more than half of pregnant women are infected with the virus. Thousands of children are orphanned by AIDS every day. Seventy per cent of HIV infected people are women and children---things have changed in the twenty five years since AIDS first surfaced in the medical journals.
Some experts opine that a successful vaccine against HIV may not even be possible. Their reasons include the fact that the outer coat or "envelop" of the virus is constantly mutating and the fact that the part of the virus that binds to the receptor to get inside a cell stealthily stays hidden until just before binding, when the envelop undergoes an energetic, spasmadic shape-change. Knowing the part of the virus that binds--the receptor attachment sequence or "key"-- is ESSENTIAL to designing a successful vaccine that will elicit neutralizing antibodies.
We understand the key scientific reason why there is not yet a successful AIDS vaccine and none on the horizon. Despite the billions spent and the vast array of movie, athletic and rock stars who are raising more money to help, the experts form a monolith--there is only one idea being tested and sadly it is inaccurate. Now bear with me: The Wiley-Sodrowski Model, based mostly on an X-ray crystal structure of an artificial viral envelop with parts cut out, claims that no simple peptide sequence serves as the key, no short string of amino acids derived from the 600 amino acid long envelop protein. Instead there is a theory about "discontinuous epitopes", different parts of the envelop folding in upon itself to form a very big key that is too ill-defined to be of practical significance in producing a vaccine. This conclusion is based mostly upon the failure to find such a short peptide sequence that blocks infectivity after an intensive university-business-government collaborative search over 20 years ago. Sadly, despite the intense effort, the strategy was flawed:
Carving the 600 amino acids long envelp into 30 "20mers" didn't work for a number of reasons that peptide pharmacologists can easily understand (eg the pituitary gland's own morphine, beta-endorphin is 31 amino acids long, but most 1-20 pieces are inactive even though they contain the 1-5 ("enkephalin") highly active piece). This is because
sequence determines shape and final SHAPE is the key.
I am certain that we will make a fruitful connection soon to share our approach. We want to help. We want to work as a team and join the vast effort that has already done the groundwork for vaccine testing. Unlike virtually ALL vaccines undergoing testing right now which contain
the entire 600 amino acid viral envelop, the short peptides we have studied can be used to create a practical, effective vaccine for the developing world that would cost only pennies per person. Current test vaccines do NOT produce neutralizing antibodies, an essential requirement for full success since. Made of the entire envelop delivered by a viral vector, they are unlikely to eradicate AIDS, probably because there is too much irrelevant information or "static" being presented to the body's immune system.
I am grateful to God for giving us the leads and the opportunity to help to create a world without AIDS. It is only a matter of time to get enough data to convince the experts to let us help. (Sorry this entry is a bit more focussed and technical than is usual, but my ISH needed to speak on this matter)
For more information regarding the experimental HIV antiviral therapeutic which is the key to a successful AIDS vaccine, please visit www.TINM.org, the website for The Institute for New Medicine.
Some experts opine that a successful vaccine against HIV may not even be possible. Their reasons include the fact that the outer coat or "envelop" of the virus is constantly mutating and the fact that the part of the virus that binds to the receptor to get inside a cell stealthily stays hidden until just before binding, when the envelop undergoes an energetic, spasmadic shape-change. Knowing the part of the virus that binds--the receptor attachment sequence or "key"-- is ESSENTIAL to designing a successful vaccine that will elicit neutralizing antibodies.
We understand the key scientific reason why there is not yet a successful AIDS vaccine and none on the horizon. Despite the billions spent and the vast array of movie, athletic and rock stars who are raising more money to help, the experts form a monolith--there is only one idea being tested and sadly it is inaccurate. Now bear with me: The Wiley-Sodrowski Model, based mostly on an X-ray crystal structure of an artificial viral envelop with parts cut out, claims that no simple peptide sequence serves as the key, no short string of amino acids derived from the 600 amino acid long envelop protein. Instead there is a theory about "discontinuous epitopes", different parts of the envelop folding in upon itself to form a very big key that is too ill-defined to be of practical significance in producing a vaccine. This conclusion is based mostly upon the failure to find such a short peptide sequence that blocks infectivity after an intensive university-business-government collaborative search over 20 years ago. Sadly, despite the intense effort, the strategy was flawed:
Carving the 600 amino acids long envelp into 30 "20mers" didn't work for a number of reasons that peptide pharmacologists can easily understand (eg the pituitary gland's own morphine, beta-endorphin is 31 amino acids long, but most 1-20 pieces are inactive even though they contain the 1-5 ("enkephalin") highly active piece). This is because
sequence determines shape and final SHAPE is the key.
I am certain that we will make a fruitful connection soon to share our approach. We want to help. We want to work as a team and join the vast effort that has already done the groundwork for vaccine testing. Unlike virtually ALL vaccines undergoing testing right now which contain
the entire 600 amino acid viral envelop, the short peptides we have studied can be used to create a practical, effective vaccine for the developing world that would cost only pennies per person. Current test vaccines do NOT produce neutralizing antibodies, an essential requirement for full success since. Made of the entire envelop delivered by a viral vector, they are unlikely to eradicate AIDS, probably because there is too much irrelevant information or "static" being presented to the body's immune system.
I am grateful to God for giving us the leads and the opportunity to help to create a world without AIDS. It is only a matter of time to get enough data to convince the experts to let us help. (Sorry this entry is a bit more focussed and technical than is usual, but my ISH needed to speak on this matter)
For more information regarding the experimental HIV antiviral therapeutic which is the key to a successful AIDS vaccine, please visit www.TINM.org, the website for The Institute for New Medicine.
